cenobamate will reduce the level or outcome of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Boost dose of CYP3A4 substrate, as necessary, when coadministered with cenobamate.The fentanyl skin patch is barely utilized for opioid-tolerant clients. A client is opioid-tolerant if